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[Part 1: Biological Sciences] || Development of Methotrexate Resistance in a Human Squamous Cell Carcinoma of the Head and Neck in Culture

✍ Scribed by Emil Frei, Andre Rosowsky, Joel E. Wright, Carol A. Cucchi, Judith A. Lippke, Thomas J. Ervin, Jacques Jolivet and William A. Haseltine


Book ID
123630921
Publisher
National Academy of Sciences
Year
1984
Tongue
English
Weight
943 KB
Volume
81
Category
Article
ISSN
0027-8424

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Methotrexate content in squamous cell ca
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## Abstract Eleven patients with squamous carcinoma of the head and neck who were scheduled for surgical resection or endoscopic biopsy of tumor received 15 mg/m^2^ of methotrexate (MTX). Samples of tumor, normal mucosa, and plasma were obtained at surgery or endoscopy, 18‐24 hours after the last M