Epidermal growth factor (EGF) may either stimulate or inhibit cell growth. To elucidate the mechanism of these varied effects, we compared EGF action in parental A431 cells in which cell growth is inhibited, and clone 15, a mutant of these cells resistant to EGF growth inhibition. In both lines, EGF
โฆ LIBER โฆ
[Part 1: Biological Sciences] || Altered Epidermal Growth Factor (EGF)-Stimulated Protein Kinase Activity in Variant A431 Cells with Altered Growth Responses to EGF
โ Scribed by Janice E. Buss, Jeffrey E. Kudlow, Cheri S. Lazar and Gordon N. Gill
- Book ID
- 123623597
- Publisher
- National Academy of Sciences
- Year
- 1982
- Tongue
- English
- Weight
- 970 KB
- Volume
- 79
- Category
- Article
- ISSN
- 0027-8424
- DOI
- 10.2307/12179
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The epidermal growth factor (EGF) receptor mediates the effects of both EGF and transforming growth factor alpha (TGFalpha). Recent data suggested that EGF acts as a partial agonist/antagonist in hepatocytes, TGFalpha exerting a larger maximal stimulation of DNA synthesis than EGF. To further study