Increased methotrexate-induced DNA stran
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Hirohiko Sano; Masaru Kubota; Yasufumi Kasai; Hisako Hashimoto; Tsunehiro Shimiz
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Article
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2007
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John Wiley and Sons
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French
⚖ 484 KB
## Abstract The cytotoxicity and DNA lesions induced by methotrexate (MTX) were compared in wild‐type, hypoxanthine‐guanine phosphoribosyltransferase‐deficient (HGPRT) and thymi‐dine‐kinase‐deficient (TK) HL‐60 cells. TK^‐^ and HGPRT cells were approximately 10 and 3 times more sensitive to MTX tha