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[Part 1: Biological Sciences] || Accumulation of DNA Strand Breaks and Methotrexate Cytotoxicity

✍ Scribed by James C. Li and Edvardas Kaminskas


Book ID
123631205
Publisher
National Academy of Sciences
Year
1984
Tongue
English
Weight
735 KB
Volume
81
Category
Article
ISSN
0027-8424

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## Abstract The cytotoxicity and DNA lesions induced by methotrexate (MTX) were compared in wild‐type, hypoxanthine‐guanine phosphoribosyltransferase‐deficient (HGPRT) and thymi‐dine‐kinase‐deficient (TK) HL‐60 cells. TK^‐^ and HGPRT cells were approximately 10 and 3 times more sensitive to MTX tha