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PARP-1, a determinant of cell survival in response to DNA damage

✍ Scribed by Véronique J. Bouchard; Michèle Rouleau; Guy G. Poirier

Book ID
114217021
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
167 KB
Volume
31
Category
Article
ISSN
0301-472X

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## Abstract Pluripotent human embryonic stem (hES) cells require mechanisms to maintain genomic integrity in response to DNA damage that could compromise competency for lineage‐commitment, development, and tissue‐renewal. The mechanisms that protect the genome in rapidly proliferating hES cells are