Paroxysmal nocturnal hemoglobinuria: An
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Nishimura, Jun-ichi; Murakami, Yoshiko; Kinoshita, Taroh
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Article
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1999
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John Wiley and Sons
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English
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Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder characterized by an intravascular hemolytic anemia. Abnormal blood cells lack a series of glycosylphosphatidylinositol (GPI)-anchored proteins. The lack of GPIanchored complement regulatory proteins, suc