✦ LIBER ✦

Parkinson's disease, subthalamic stimulation, and selection of candidates: A pathological study

✍ Scribed by Bechir Jarraya; Anne-Marie Bonnet; Charles Duyckaerts; Jean-Luc Houeto; Philippe Cornu; Jean-Jacques Hauw; Yves Agid

Publisher: John Wiley and Sons
Year: 2003
Tongue: English
Weight: 165 KB
Volume: 18
Category: Article
ISSN: 0885-3185
DOI: 10.1002/mds.10607

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

We report on a patient with Parkinson's disease (PD) who was moderately improved by stimulation of the subthalamic nucleus (STN) and died 2 years after electrode implantation. After neurosurgery, symptoms that had responded to levodopa treatment preoperatively continued to improve. Postural instability, dysarthria, and cognitive impairment continued to worsen, despite STN stimulation and levodopa treatment. Postmortem examination of the brain confirmed the diagnosis of PD and showed that the electrodes had been correctly positioned within the STN. The failure of STN stimulation in this patient confirms the importance of screening and excluding patients from surgery with evolving parkinsonian axial symptoms or cognitive impairment. © 2003 Movement Disorder Society

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