Parkinson's disease: changes in apoptosis-related factors suggesting possible gene therapy

Reversible neurochemical changes mediate

Reversible neurochemical changes mediated by delayed intrastriatal glial cell line-derived neurotrophic factor gene delivery in a partial Parkinson's disease rat model

✍ Xin Yang; Birgit Mertens; Enni Lehtonen; Linda Vercammen; Olivier Bockstael; Abd 📂 Article 📅 2009 🏛 John Wiley and Sons 🌐 English ⚖ 593 KB

## Abstract ## Background Efficient protection of dopaminergic neurons against a subsequent 6‐hydroxydopamine lesion by glial cell line‐derived neurotrophic factor (GDNF) gene delivery has been demonstrated. By contrast, the neurorestorative effects of GDNF administered several weeks after the tox