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Parkinson's disease: A broken nosology

✍ Scribed by John Hardy; Andrew J. Lees

Book ID
102505984
Publisher
John Wiley and Sons
Year
2005
Tongue
English
Weight
45 KB
Volume
20
Category
Article
ISSN
0885-3185

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✦ Synopsis

Parkinson's disease (PD) is a clinical diagnosis. We argue here that if we are to make progress in understanding its underlying pathogenesis, there is a need to have a pathological definition of disease that includes the presence of Lewy bodies and nigral loss in the ventrolateral tier of the pars compacta of the substantia nigra. Using such a definition, there is only one certain and known cause: mutations in the alpha-synuclein gene. However, the phenotype of this one known cause is broader than PD and encompasses Lewy body dementia.

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