Parkinsonism, dementia and glucocerebrosidase mutations
β Scribed by Kathryn Peall, Neil P. Robertson
- Book ID
- 120898574
- Publisher
- Springer
- Year
- 2013
- Tongue
- English
- Weight
- 161 KB
- Volume
- 260
- Category
- Article
- ISSN
- 0340-5354
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π SIMILAR VOLUMES
## Abstract Mutations in the glucocerebrosidase gene are associated with Parkinson's disease and Lewy body dementia. However, whether these alterations have any effect on the clinical course of Parkinson's disease is not clear. The glucocerebrosidase coding region was fully sequenced in 225 Parkins
## Abstract A body of work has emerged over the past decade demonstrating a relationship between mutations in glucocerebrosidase gene (__GBA__), the gene implicated in Gaucher disease (GD), and the development of parkinsonism. Several different lines of research support this relationship. First, pa