## Abstract The identification of the widespread deposition of fibrillized α‐synuclein in Lewy bodies and Lewy neurites in the brains of patients with Parkinson's disease in 1997 has had a profound impact on how the disease is now conceptualized. The previous focus on the loss of the dopaminergic n
✦ LIBER ✦
Parkinson disease: Insights in clinical, genetic and pathological features of monogenic disease subtypes
✍ Scribed by David Crosiers; Jessie Theuns; Patrick Cras; Christine Van Broeckhoven
- Book ID
- 116620238
- Publisher
- Elsevier Science
- Year
- 2011
- Tongue
- English
- Weight
- 977 KB
- Volume
- 42
- Category
- Article
- ISSN
- 0891-0618
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Motor dysfunction and cognitive impairment are major symptoms in both Huntington’s Disease (HD) and Parkinson’s Disease (PD). A breakthrough in HD research was the identification of the gene that causes this devastating monogenetic illness. Similarly, several genes were found to cause familial forms