✦ LIBER ✦

PARK2 mutations and clinical features in a Chinese population with early-onset Parkinson’s disease

✍ Scribed by Daniel Kam Yin Chan; Vincent Mok; Ping Wing Ng; Jonas Yeung; John B. Kwok; Zhi Ming Fang; Raymond Clarke; Lawrence Wong; Peter R. Schofield; Nobutaka Hattori

Publisher: Springer
Year: 2008
Tongue: English
Weight: 151 KB
Volume: 115
Category: Article
ISSN: 1435-1463
DOI: 10.1007/s00702-007-0011-6

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

LRRK2 Gly2385Arg mutation and clinical f

LRRK2 Gly2385Arg mutation and clinical features in a Chinese population with early-onset Parkinson’s disease compared to late-onset patients

✍ Daniel Kam Yin Chan; Ping Wing Ng; Vincent Mok; Jonas Yeung; Zhi Ming Fang; Raym 📂 Article 📅 2008 🏛 Springer 🌐 English ⚖ 145 KB

Recurrent LRRK2 (Park8) mutations in ear

Recurrent LRRK2 (Park8) mutations in early-onset Parkinson's disease

✍ Katja Hedrich; Susen Winkler; Johann Hagenah; Kemal Kabakci; Meike Kasten; Eberh 📂 Article 📅 2006 🏛 John Wiley and Sons 🌐 English ⚖ 95 KB 👁 1 views

## Abstract Mutations in __LRRK2__ (__leucine‐rich repeat kinase 2__) have been associated with autosomal dominant Parkinson's disease (PD) and cluster in several 3′ exons of the gene. The majority of mutations have been detected in late‐onset cases (age at onset >50 years). We screened 5 of the 51

parkin mutation analysis in clinic patie

parkin mutation analysis in clinic patients with early-onset Parkinson's disease

✍ Poorkaj, P. ;Nutt, J. G. ;James, D. ;Gancher, S. ;Bird, T. D. ;Steinbart, E. ;Sc 📂 Article 📅 2004 🏛 John Wiley and Sons 🌐 English ⚖ 164 KB 👁 2 views

Prevalence and clinical features of comm

Prevalence and clinical features of common LRRK2 mutations in Australians with Parkinson's Disease

✍ Yue Huang; Glenda M. Halliday; Himesha Vandebona; George D. Mellick; Frank Masta 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 116 KB 👁 1 views

## Abstract We determined the prevalence of two common leucine‐rich repeat kinase 2 (LRRK2) gene mutations in Australian patients with Parkinson's disease (PD). Of 830 affected patients, eight were heterozygous for the G2019S mutation, and two were heterozygous for the R1441H (4,322 G > A) mutation

PLA2G6 mutations in PARK14-linked young-

PLA2G6 mutations in PARK14-linked young-onset parkinsonism and sporadic Parkinson's disease

✍ Chin-Song Lu; Szu-Chia Lai; Ruey-Meei Wu; Yi-Hsin Weng; Chia-Ling Huang; Rou-Sha 📂 Article 📅 2011 🏛 John Wiley and Sons 🌐 English ⚖ 458 KB 👁 2 views

## Abstract Mutations of __PLA2G6__ gene have been lately proposed to be the causative gene for PARK14 in patients with autosomal recessive young‐onset parkinsonism (YOPD). The role of __PLA2G6__ mutations as a risk factor for Parkinson's disease is not clear. To study the __PLA2G6__ mutations in P

Novel parkin mutations detected in patie

Novel parkin mutations detected in patients with early-onset Parkinson's disease

✍ Aida M. Bertoli-Avella; José L. Giroud-Benitez; Ali Akyol; Egberto Barbosa; Onno 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 141 KB

## Abstract A multiethnic series of patients with early‐onset Parkinson's disease (EOP) was studied to assess the frequency and nature of __parkin__/PARK2 gene mutations and to investigate phenotype–genotype relationships. Forty‐six EOP probands with an onset age of <45 years, and 14 affected relat