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PARK2 and PACRG are commonly downregulated in clear-cell renal cell carcinoma and are associated with aggressive disease and poor clinical outcome

โœ Scribed by Toma, Marieta I.; Wuttig, Daniela; Kaiser, Sandy; Herr, Alexander; Weber, Thomas; Zastrow, Stefan; Koch, Rainer; Meinhardt, Matthias; Baretton, Gustavo B.; Wirth, Manfred P.; Fuessel, Susanne


Book ID
118758905
Publisher
John Wiley and Sons
Year
2012
Tongue
English
Weight
675 KB
Volume
52
Category
Article
ISSN
1045-2257

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## Abstract We attempted to describe, in a series of clear cell renal cell carcinoma (RCC), the relationship between CAIX expression, VHL gene mutations, tumor characteristics and outcome. Radical nephrectomy was performed in 100 patients. Genomic DNA was extracted from frozen tumor samples. Four a