Pargyline-Sensitive selective accumulation of a radiolabeled MPTP analog in the primate cerebral cortex and basal ganglia
✍ Scribed by S. M. N. Efange; H. F. Kung; D. C. Mash; M. Jabir; J. Billings; J. Pablo; A. Dutta; A. Freshler
- Publisher
- John Wiley and Sons
- Year
- 1990
- Tongue
- English
- Weight
- 759 KB
- Volume
- 5
- Category
- Article
- ISSN
- 0887-4476
No coin nor oath required. For personal study only.
✦ Synopsis
The distribution of radioiodinated N-methyl-4-(4-hydroxy-3-iodobenzyl)-1,2,3,6-tetrahydropyridine (MHTP), an analog of the reportedly nontoxic N-methyl-4-benzyl-1,2,3,6-tetrahydropyridine, (4-homo-MPTP1, has been studied in the primate.
[ lZ3I]MHTP-derived radioactivity exhibited a progressive accumulation and prolonged retention within the primate eye. Following iv injection, [12311MHTP rapidly accumulated within the primate brain and was subsequently oxidized to a radiolabeled metabolite. The half-life of [12311MHTP-derived radioactivity within the primate brain was 50 min. The highest concentrations of radioactivity were found in the caudate-putamen and the frontal, temporal and cingulate cortices; the substantia nigra and inferior olivary nucleus were labeled with medium intensity. Very low concentrations of radiolabel were detected in the cerebellum and white matter. Selective accumulation of [lZ5I]MHTP-derived radioactivity within these structures was blocked by pretreatment with pargyline, suggesting that monoamine oxidase B is involved in the bioactivation of radioiodinated [ 12511MHTP, Monoamine oxidase, MHTP, 4-Homo-MPTP v MfiyP.