✦ LIBER ✦

Parental sex effects in bipolar affective disorder pedigrees

✍ Scribed by J.A. Donald; J.A. Salmon; L.J. Adams; T. Littlejohn; A. Maher; P.B. Mitchell; P.R. Schofield

Publisher: John Wiley and Sons
Year: 1997
Tongue: English
Weight: 32 KB
Volume: 14
Category: Article
ISSN: 0741-0395
DOI: 10.1002/(sici)1098-2272(1997)14:6<611::aid-gepi10>3.0.co;2-t

No coin nor oath required. For personal study only.

✦ Synopsis

A combined linkage analysis was performed on chromosome 18 data and produced modest evidence in three of four data sets for linkage of a susceptibility locus for bipolar disorder to markers on chromosome 18p. All data sets showed a preponderance of females among affected individuals. When this was taken into account, no convincing evidence was obtained for excess transmission from mothers compared to fathers. In addition, there was no evidence for differences in the proportions of affected offspring from affected fathers and mothers. We conclude that these combined data do not support previous suggestions of a maternal effect on transmission of bipolar affective disorder.

📜 SIMILAR VOLUMES

Parental transmission and D18S37 allele

Parental transmission and D18S37 allele sharing in bipolar affective disorder

✍ JingPing Lin; Sherri J. Bale 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 22 KB

We combined the five chromosome 18 bipolar affective disorder data sets provided by GAW10, totaling 185 families with 3,394 individuals, and performed analysis of differential parental transmission and chromosome 18 marker allele sharing in families with transmission through fathers vs those through

Patterns of parental transmission and fa

Patterns of parental transmission and familial aggregation models in bipolar affective disorder

✍ Grigoroiu-Serbanescu, Maria; Martinez, Maria; N�then, Markus M.; Propping, Peter 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 42 KB 👁 2 views

reported an excess of maternal transmission in bipolar affective disorder in multiply affected families. In a sample of 130 families ascertained through a bipolar proband without regard to psychiatric family history we analysed the frequency of maternal (MAT) and paternal (PAT) transmissions, the mo

Exclusion of Linkage Between Bipolar Aff

Exclusion of Linkage Between Bipolar Affective Disorder and Chromosome 16 in 12 Australian Pedigrees

✍ Adams, Linda J.; Salmon, Judy A.; Kwok, John B.; Vivero, Christina; Donald, Jenn 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 218 KB 👁 2 views

Several recent reports of possible susceptibility loci for bipolar affective disorder (BAD) have identified sites on a number of chromosomes. Specifically, two Danish studies have suggested the presence of a susceptibility locus for BAD on chromosome 16p13. As the first step of a whole genome scan,

Genetic heterogeneity in a very large bi

Genetic heterogeneity in a very large bipolar affective disorder pedigree from Quebec

✍ Shink, E. ;Morissette, J. ;Barden, N. 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 101 KB 👁 2 views

Possible parent-of-origin effect of Dopa

Possible parent-of-origin effect of Dopa decarboxylase in susceptibility to bipolar affective disorder

✍ A.D. Børglum; G. Kirov; N. Craddock; O. Mors; W. Muir; V. Murray; I. McKee; D.A. 📂 Article 📅 2001 🏛 John Wiley and Sons 🌐 English ⚖ 64 KB 👁 1 views

Parent-of-origin effect in transmission

Parent-of-origin effect in transmission of bipolar disorder

✍ Kato, Tadafumi; Winokur, George; Coryell, William; Keller, Martin B.; Endicott, 📂 Article 📅 1996 🏛 John Wiley and Sons 🌐 English ⚖ 580 KB

Recently, possible inv Dlvement of a parentof-origin effect in the transmission of bipolar disorder has been suggested. We examined the possible contribution of parent-of-origin effect by using data from a large family and family history study of bipolar patients in the Collaborative Depression Stud