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Parental Origin and Timing of De Novo Robertsonian Translocation Formation

✍ Scribed by Ruma Bandyopadhyay; Anita Heller; Cami Knox-DuBois; Christopher McCaskill; Sue Ann Berend; Scott L. Page; Lisa G. Shaffer


Book ID
117854076
Publisher
American Society of Human Genetics
Year
2002
Tongue
English
Weight
238 KB
Volume
71
Category
Article
ISSN
0002-9297

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Molecular analysis of mosaicism for two
✍ Berend, Sue Ann; CanοΏ½n, Sonia; McCaskill, Christopher; Page, Scott L.; Shaffer, πŸ“‚ Article πŸ“… 1998 πŸ› John Wiley and Sons 🌐 English βš– 45 KB

Robertsonian translocations (ROBs) involving chromosome 21 occur in about 5% of individuals with Down syndrome. ROBs are the most common chromosomal rearrangements in humans and are formed through whole arm exchanges of any two acrocentric chromosomes. The de novo formation of ROBs occurs at excepti