Parental cigarette smoking and the risk of acute leukemia in children

✍ Scribed by Jack Brondum; Xiao-Ou Shu; Michael Steinbuch; Richard K. Severson; John D. Potter; Leslie L. Robison

• Publisher: John Wiley and Sons
• Year: 1999
• Tongue: English
• Weight: 102 KB
• Volume: 85
• Category: Article
• ISSN: 0008-543X
• DOI: 10.1002/(sici)1097-0142(19990315)85:6<1380::aid-cncr23>3.0.co;2-o

✦ Synopsis

BACKGROUND.

Studies of the relation between parental smoking and childhood leukemia have produced inconsistent results. In the largest case-control studies of childhood acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML) conducted to date, the authors evaluated leukemia risk relative to parental selfreport of cigarette smoking.

METHODS.

In telephone interviews in which a structured questionnaire was used, parents of 1842 ALL patients, 517 AML patients, and their matched controls were asked about their cigarette smoking habits before, during, and after the pregnancy with the index child. Risk of leukemia was examined by histologic type, age of the child at diagnosis, immunophenotype (for ALL), and French-American-British morphology group (for AML).

RESULTS.

The risk of ALL was not associated with the father's ever having smoked (odds ratio [OR] ϭ 1.04, 95% confidence interval [CI] 0.90 -1.20) or the mother's ever having smoked (OR ϭ 1.04, 95% CI 0.91-1.19). Similarly, no significant risk of AML was observed for paternal (OR ϭ 0.88, 95% CI 0.67-1.16) or maternal smoking 1380