Sclerostin antibody treatment enhances m
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Fredrik Agholme; Xiaodong Li; Hanna Isaksson; Hua Zhu Ke; Per Aspenberg
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Article
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2010
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American Society for Bone and Mineral Research
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English
β 284 KB
## Abstract Sclerostin is the product of the __SOST__ gene. Lossβofβfunction mutations in the __SOST__ gene result in a highβboneβmass phenotype, demonstrating that sclerostin is a negative regulator of bone mass. Primarily expressed by osteocytes in bone, sclerostin is reported to bind the LRP5/6