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Parc-ing p53 in the Cytoplasm

✍ Scribed by Michael B. Kastan; Gerard P. Zambetti


Book ID
117269387
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
81 KB
Volume
112
Category
Article
ISSN
0092-8674

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Previous studies have shown that nuclear p53 over-expression is an indicator of p53 mutations whereas cytoplasmic p53 accumulation is related to wild-type p53 in several kinds of tumors. Cytoplasmic p53 accumulation has been demonstrated to be an independent prognostic factor in colorectal adenocarc