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Parathyroidectomy and the induction of thymic atrophy in normal, adrenalectomized and orchidectomized rats

✍ Scribed by A. D. Perris; L. A. Weiss; J. F. Whitfield

Publisher
John Wiley and Sons
Year
1970
Tongue
English
Weight
655 KB
Volume
76
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Parathyroidectomy or thyroparathyroidectomy in the male rat results in the severe atrophy of the thymus gland. This effect is not mediated by a secondary release of the cytolytic adrenal or gonadal steroids since it also occurs in adrenalectomized and orchidectomized animals. The loss of the parathyroid gland decreases the flow of thymic lymphocytes into mitosis; this inhibition of cell production leads to the marked decline in thymic weight. The effect can be partially prevented by administration of parathyroid hormone or calcium gluconate.

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## Background: The intralobular distribution of activity of glycogen phosphorylase (gp), a key enzyme in the breakdown of glycogen, was evaluated to determine changes during early glycogen synthesis. hepatic gp activity was localized in normal and adrenalectomized (adx) rats after fasting overnight