Parathyroid hormone stimulates phosphoinositide metabolism and intracellular calcium mobilization in osteoblast-like clone MC3T3-E1 cells

Regulation of matrix Gla protein by para

Regulation of matrix Gla protein by parathyroid hormone in MC3T3-E1 osteoblast-like cells involves protein kinase A and extracellular signal-regulated kinase pathways

✍ Supaporn Suttamanatwong; Renny T. Franceschi; Ann E. Carlson; Rajaram Gopalakris 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 237 KB 👁 1 views

## Abstract Inhibition of osteoblast‐mediated mineralization is one of the major catabolic effects of parathyroid hormone (PTH) on bone. Previously, we showed that PTH induces matrix γ‐carboxyglutamic acid (Gla) protein (MGP) expression and established that this induction is critical for PTH‐mediat