Parathyroid hormone regulation of bone sialoprotein (BSP) gene transcription is mediated through a pituitary-specific transcription factor-1 (Pit-1) motif in the rat BSP gene promoter

Transforming growth factor-β1 regulation

Transforming growth factor-β1 regulation of bone sialoprotein gene transcription: Identification of a TGF-β activation element in the rat BSP gene promoter

✍ Yorimasa Ogata; Naomi Niisato; Shunsuke Furuyama; Sela Cheifetz; Richard H. Kim; 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 186 KB 👁 1 views

Transforming growth factor-b (TGF-b) increases steady-state mRNA levels of several extracellular matrix proteins in mineralized connective tissues. Bone sialoprotein (BSP) is a major constituent of the bone matrix, thought to initiate and regulate the formation of mineral crystals. To determine the