Intermittent administration of parathyroid hormone (PTH) activates new sites of bone formation by stimulating osteoblast differentiation and function resulting in an increase in bone mass. Because integrins have been shown to play a crucial role in osteoblast differentiation and bone formation, in t
Parathyroid Hormone Regulates Histone Deacetylases in Osteoblasts
β Scribed by EMI SHIMIZU; NAGARAJAN SELVAMURUGAN; JENNIFER J. WESTENDORF; NICOLA C. PARTRIDGE
- Book ID
- 111483562
- Publisher
- John Wiley and Sons
- Year
- 2007
- Tongue
- English
- Weight
- 73 KB
- Volume
- 1116
- Category
- Article
- ISSN
- 0890-6564
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Parathyroid hormone (PTH) has been shown to induce osteoblastic activity via a complex signal transduction process which is mediated either by cAMP or cytosolic calcium ([Ca2+]i), or a combination thereof. One of the PTH functions in osteoblasts is the induction of ornithine decarboxylase (ODC) acti
Parathyroid hormone (PTH) receptors and the biological response to PTH in osteoblasts have been shown to be influenced by glucocorticoids, growth factors, cytokines or PTH itself. Furthermore, components of extracellular matrix (ECM) appear to regulate the response to PTH as well. We investigated th