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Parathyroid hormone and isoproterenol stimulation of adenylate cyclase in rat osteosarcoma clonal cells Hormone competition and site heterogeneity

✍ Scribed by Rodan, Sevgi B.; Rodan, Gideon A.

Book ID
121782258
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
502 KB
Volume
673
Category
Article
ISSN
0304-4165

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ROS17/2.8 cells, a cell line derived from a rat osteosarcoma, have abundant receptors for parathyroid hormone (PTH) and parathyroid hormone-related peptide (PTHrP). A particulate membrane fraction was prepared from these cells and it was solubilized using relatively mild conditions with digitonin (0