Parathyroid hormone and calcitonin secretion in uraemic infants

✍ Scribed by G. Zamboni; M. Cecchettin; G. Zoppi

• Publisher: Springer
• Year: 1978
• Tongue: English
• Weight: 414 KB
• Volume: 129
• Category: Article
• ISSN: 0340-6997
• DOI: 10.1007/bf00442162

✦ Synopsis

In six infants aged between 4 and 8 months with chronic renal failure, we have studied blood levels of calcium (Ca), phosphorus (P), alkaline phosphatase, immunoreactive parathyroid hormone (PTH), and calcitonin (CT), as well as urinary excretion of Ca, P, hydroxyproline and cyclic AMP under basal conditions and during an infusion of 2 0 m g / k g of 10% Ca gluconate in normal saline over 4h.

Under basal conditions four infants had normal serum Ca and P values, alkaline phosphatase levels at the upper limit of normal, and very high PTH (range: 1450--2550 pg Eq/ml) and CT (range: 700--1900 pg/ml) levels. The urinary Ca excretion was low, whereas the urinary excretion of P, hydroxyproline and cyclic AMP was high. During Ca infusion, the total serum Ca and CT levels increased, P T H fell without however reaching the normal upper limit, and urinary P and cyclic AMP excretion decreased. In two infants with osteodystrophy and the highest levels of P T H (2900 and 3500pg Eq/ml respectively) there was no suppression of PTH during Ca infusion.