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Parasite glycoconjugates. Part 12.1 Synthesis of deoxy, fluorodeoxy and aminodeoxy disaccharide phosphates, substrate analogues for the elongating α-D-mannopyranosylphosphate transferase in the Leishmania


Book ID
126734677
Publisher
Royal Society of Chemistry
Year
2001
Weight
305 KB
Volume
2
Category
Article
ISSN
1472-7781

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Synthesis of β-d-Galp-(1→4)-α-d-Manp met
✍ Vladimir S Borodkin; Michael A.J Ferguson; Andrei V Nikolaev 📂 Article 📅 2001 🏛 Elsevier Science 🌐 French ⚖ 86 KB

An isosteric C-glycoside phosphono analogue of dec-9-enyl b-D-galactopyranosyl-( 14)-a-D-mannopyranosyl phosphate was synthesised and showed high biological activity in the Leishmania MPT assay. A one-step Horner-Emmons/Michael reaction was developed for the stereoselective preparation of a-D-mannos