Paraquat poisoning in man

✍ Scribed by A. Dijk; R. A. A. Maes; R. H. Drost; J. M. C. Douze; A. N. P. Heyst

• Book ID: 104736242
• Publisher: Springer-Verlag
• Year: 1975
• Tongue: English
• Weight: 429 KB
• Volume: 34
• Category: Article
• ISSN: 0340-5761
• DOI: 10.1007/bf00353313

✦ Synopsis

In three cases of intoxication by Gramoxone¿, the concentration of paraquat dichloride in blood, dialysate, feces, and urine was determined spectrophotometrically after a clean-up of the biological material by means of ion exchange chromatography (with Dowex 50W-X12 or Zeo-Karb 225). Although good results were obtained after clean-up with Dowex 50W-X12, Zeo-Karb was preferred as ion exchange resin, especially when large sample volumes were needed for the determination. The reported findings indicate that: only 5 to 10% of an ingested dose of paraquat dichloride is absorbed in man, Fullers' earth is very useful, and that primary, e.g. immediate, hemodialysis is necessary.