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Paraquat increases connective tissue growth factor and collagen expression via angiotensin signaling pathway in human lung fibroblasts

✍ Scribed by Jai-Nien Tung; Yaw-Dong Lang; Leng-Fang Wang; Chung-Ming Chen


Book ID
116920194
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
411 KB
Volume
24
Category
Article
ISSN
0887-2333

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## Abstract Transforming growth factor‐β (TGF‐β) and interleukin‐4 (IL‐4) have fibrogenic properties and induce extracellular matrix production in a variety of lung diseases. Connective tissue growth factor (CTGF) is a matrix signaling molecule stimulated by TGF‐β that in part mediates Ξ±1(I) collag