Paraoxonase gene Gln192Arg (Q192R) polymorphism is associated with coronary artery spasm
โ Scribed by Teruhiko Ito; Hirofumi Yasue; Michihiro Yoshimura; Shota Nakamura; Masafumi Nakayama; Yukio Shimasaki; Eisaku Harada; Yuji Mizuno; Hiroaki Kawano; Hisao Ogawa
- Publisher
- Springer
- Year
- 2001
- Tongue
- English
- Weight
- 44 KB
- Volume
- 110
- Category
- Article
- ISSN
- 0340-6717
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## Abstract __Purpose__: To investigate the association of matrix metalloproteinaseโ9 (MMPโ9) and paraoxonase 1 (PON1) 192 polymorphisms with susceptibility to coronary artery stenosis (CAS) and the number of diseased vessels in patients with CAS. __Methods__: The study population comprised 302 unr
## Abstract Paraoxonase 1 (PON 1) is a highโdensity lipoprotein (HDL)โassociated enzyme with antioxidant function protecting lowโdensity lipoprotein (LDL) from oxidation. PON 1 has two amino acid polymorphisms in coding region; L/M 55 and Q/R 192. These polymorphisms modulate paraoxonase activity o