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Paraoxonase 2 (PON2) polymorphisms and Parkinson's disease

✍ Scribed by Lucio G. Costa; Samir N. Kelada; Paola Costa-Mallen; Fred M. Farin; Hannah A. Viernes; Terri Smith Weller; Gary M. Franklin; William T. Longstreth; Philip D. Swanson; Harvey Checkoway; Clement E. Furlong

Publisher: John Wiley and Sons
Year: 2004
Tongue: English
Weight: 743 KB
Volume: 34
Category: Article
ISSN: 0893-6609
DOI: 10.1002/nrc.20008

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Paraoxonase1 (PON1) is an arylesterase mainly expressed in the liver that hydrolyzes organophosphates such as pesticides, reported risk factors for Parkinson's disease (PD), and other neurotoxins. A Leu-Met 54 polymorphism in the gene for PON1-affecting enzyme activity was recently shown, employing