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Paraneoplastic glomerulopathy secondary to retroperitoneal sarcoma: A case report

✍ Scribed by Jingjing L. Sherman; Eric Y. Liu; Junko Ozao-Choy; Jonathan A. Winston; Johnny Lee; Steven H. Dikman; Celia M. Divino

Publisher
John Wiley and Sons
Year
2010
Tongue
English
Weight
534 KB
Volume
102
Category
Article
ISSN
0022-4790

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✦ Synopsis

Abstract

Glomerulopathy is a rare form of paraneoplastic disease. We present the second reported case of paraneoplastic glomerulopathy due to a retroperitoneal sarcoma. The patient presented with generalized edema and nephrotic syndrome. CT scan showed two large retroperitoneal masses. One large retroperitoneal mass was resected. Post‐operatively, she developed kidney failure and biopsy showed minimal change disease. With steroid therapy, patient's symptoms went into remission. We hypothesize that minimal change paraneoplastic glomerulopathy developed due to damage from cytokines released from a T‐cell mediated response to the malignancy. J. Surg. Oncol. 2010;102:704–705. Β© 2010 Wiley‐Liss, Inc.

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