We consider the problem of aligning of k sequences of length n. The cost function is sum of pairs, and satisfies triangle inequality. Earlier results on finding approximation algorithms for this problem are due to Gusfield (1991) who achieved an approximation ratio of 2 -2/k, and Pevzner (1992) who
Parametric and ensemble sequence alignment algorithms
โ Scribed by Michael S. Waterman
- Publisher
- Springer
- Year
- 1994
- Tongue
- English
- Weight
- 1020 KB
- Volume
- 56
- Category
- Article
- ISSN
- 1522-9602
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โฆ Synopsis
Proceedings of the Third Annual ACM-SIAM Discrete
Algorithms) find optimal scores for all penalty parameters, both for global and local sequence alignment. This paper reviews those techniques Then in the main part of this paper dynamic programming methods are used to compute ensemble alignment, finding all alignment scores for all parameters. Both global and local ensemble alignments are studied, and parametric alignment is used to compute near optimal ensemble alignments.
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Sequence alignment programs such as BLAST and PSI-BLAST are used routinely in pairwise, profile-based, or intermediate-sequencesearch (ISS) methods to detect remote homologies for the purposes of fold assignment and comparative modeling. Yet, the sequence alignment quality of these methods at low se