𝔖 Bobbio Scriptorium
✦   LIBER   ✦

Parameters of protection against ultraviolet radiation-induced skin cell damage

✍ Scribed by Cong Cao; Yinsheng Wan

Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
353 KB
Volume
220
Category
Article
ISSN
0021-9541

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

Epidemiological and experimental evidence has supported the notion that solar ultraviolet (UV) radiation is the leading cause of skin cell damage and skin cancer. Non‐melanoma skin cancer, one of the malignancies with the most rapidly increasing incidence, is suggested to be directly related to the total exposure to solar UV light. Over the past few years, the mechanisms of cellular responses to UV radiation have received unprecedented attention. Understanding how skin cells respond to UV radiation will undoubtedly help decipher what goes wrong in a variety of clinical skin disorders including skin cancer and will facilitate the development of novel therapeutic strategies. In the past decade, studies have established that UV radiation induces multifarious signal transduction pathways, some of which lead to apoptotic cell death, while others protect against this process. In this review, we summarize some of the most recent progresses regarding the involvement of multiple signal pathways in UV radiation‐induced apoptosis in skin cells, especially in keratinocytes. These pathways include pro‐apoptosis components such as MAPK, AMPK, and p53 as well as pro‐survival components, namely, AKT and mTORC complexes. J. Cell. Physiol. 220: 277–284, 2009. © 2009 Wiley‐Liss, Inc.

📜 SIMILAR VOLUMES

ATP-sensitive potassium channel: A novel
ATP-sensitive potassium channel: A novel target for protection against UV-induced human skin cell damage
✍ Cong Cao; Sarah Healey; Ashley Amaral; Avery Lee-Couture; Shu Wan; Nicola Koutta 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 English ⚖ 772 KB

## Abstract Ultraviolet radiation (UV) induces cell damages leading to skin photoaging and skin cancer. ATP‐sensitive potassium (K~ATP~) channel openers (KCOs) have been shown to exert significant myocardial preservation and neuroprotection in vitro and in vivo, and yet the potential role of those

Dendritic epidermal T-cell involvement i
Dendritic epidermal T-cell involvement in induction of CD8+ T cell-mediated immunity against an ultraviolet radiation-induced skin tumor
✍ Lois L. Cavanagh; Ross StC. Barnetson; Antony Basten; Gary M. Halliday 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 French ⚖ 176 KB 👁 2 views

Murine epidermis contains 2 distinct cell populations which contribute to the skin immune system, Langerhans cells (LC), and dendritic epidermal T cells (DETC). LCs are important in the induction of immunity against a wide range of antigens; however, the function of DETC is unclear. To investigate t

Exogenous catalase introduced in CHO cel
Exogenous catalase introduced in CHO cells by electroporation does not protect against chromosome damage induced by ionizing radiation.
✍ Felipe Cortés; Inmaculada Domı́nguez; Björn Sandström 📂 Article 📅 1994 🏛 Elsevier Science 🌐 English ⚖ 393 KB

## ABSTRACT The relative importance of hydrogen peroxide generated as a consequence of irradiation with X‐rays for the production of chromosomal aberrations has been studied in cultured CHO cells. Catalase introduced into cells by electroporation protected DNA from strand breakage induced by hydrog

Protective effects of the amino acid glu
Protective effects of the amino acid glutamine and of ascorbic acid against chromosomal damage induced by doxorubicin in mammalian cells
✍ Denise Crispim Tavares; Andréa O. Cecchi; Lusânia M. G. Antunes; Catarina S. Tak 📂 Article 📅 1998 🏛 John Wiley and Sons 🌐 English ⚖ 37 KB 👁 2 views

The interaction of antioxidants can provide an essential protection against the damaging effects of free radicals. Beneficial interactions include radioprotection, protection against acute toxicity of chemicals, and antimutagenic and anticarcinogenic activity. The present study was undertaken to eva