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Parameters identification and optimal control in pharmacokinetics

✍ Scribed by Y. Cherruault; M. Guerret

Publisher
Springer Netherlands
Year
1983
Tongue
English
Weight
680 KB
Volume
1
Category
Article
ISSN
0167-8019

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✦ Synopsis

We first introduce some main problems in pharmacokinetics and then we propose methods for their resolut~on. Of course, identification problem is considered. A numerical efficient method is given. It brings back to the resolution of a succession of linear algebraic systems. In the case of non unicity we suggest an approach based on the adjunction or a criterion to minimize. The last part studies the optimal injection of a drug associated to an optimization criterion. An explicit solution can be found for a ncompartments linear system.

πŸ“œ SIMILAR VOLUMES

Optimal Walsh function input signals for
Optimal Walsh function input signals for parameter identification in identification systems
✍ E.V. Bohn πŸ“‚ Article πŸ“… 1985 πŸ› Elsevier Science 🌐 English βš– 371 KB

Orthogonality of Walsh functions is used to obtain independent parameter estimation equations for continuoustime dynamic systems. The conditioning of these equations is optimized by use of optimum inpqts and is based on maximizing analytic nowlinear functions of Walsh coefficients. ## It is shown