✦ LIBER ✦

Paralogs and mutational robustness linked through transcriptional reprogramming

✍ Scribed by Eugene V. Koonin

Publisher: John Wiley and Sons
Year: 2005
Tongue: English
Weight: 93 KB
Volume: 27
Category: Article
ISSN: 0265-9247
DOI: 10.1002/bies.20296

No coin nor oath required. For personal study only.

✦ Synopsis

Abstract

A recent analysis of genome‐wide expression patterns and regulatory motif content of paralogous yeast genes1 strongly suggests that mutational robustness (backup) between paralogous genes is achieved via transcriptional reprogramming of one paralog to compensate for the loss or silencing of the other. BioEssays 27:865–868, 2005. Published 2005 Wiley Periodicals, Inc.

📜 SIMILAR VOLUMES

Genomic and transcription studies as dia

Genomic and transcription studies as diagnostic tools for a prenatal detection of X-linked dilated cardiomyopathy due to a dystrophin gene mutation

✍ Paola Rimessi; Francesca Gualandi; Laurence Duprez; Pietro Spitali; Marcella Ner 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 88 KB 👁 1 views

X-linked dilated cardiomyopathy (XLDC) represents a form of dystrophinopathy with exclusive heart involvement. Here a prenatal diagnosis of this condition performed in a family with XLDC is described. In this family, the causative mutation was a pure intronic deletion, which induces the splicing of