Parallel synthesis of unsymmetrically substituted tetraphenyl porphyrins on Wang resin

✍ Scribed by Baolu Shi; Martin Scobie; Ross W. Boyle

• Book ID: 104253827
• Publisher: Elsevier Science
• Year: 2003
• Tongue: French
• Weight: 119 KB
• Volume: 44
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(03)01142-0

✦ Synopsis

A method for synthesizing combinatorial libraries of unsymmetrically substituted tetra-meso-phenyl porphyrins on polystyrene based resin is described. Attachment of 5,15-dibromo-10-(4-hydroxyphenyl)-20-(4-nitrophenyl)porphyrin onto brominated Wang resin gave a convenient scaffold for the synthesis of photoactive porphyrin libraries with three points for generating diversity. An array of nine TPP derivatives was prepared by sequential Suzuki coupling/nitro-reduction and acylation protocols.