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Parallel Synthesis of Novel 3-Substituted 1-Ethyl-6-methylpyrimido[4,5-c]pyridazine-5,7(1 H ,6 H )-dione Analogs

✍ Scribed by Chen, Yongsheng; Barber, Jack R.; Ng, Shi Chung; Zhou, Yuefen


Book ID
121877038
Publisher
Taylor and Francis Group
Year
2010
Tongue
English
Weight
239 KB
Volume
40
Category
Article
ISSN
0039-7911

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A novel synthesis of 3-(substituted)pyri
✍ Anjanette J. Turbiak; Jeff W. Kampf; H.D. Hollis Showalter πŸ“‚ Article πŸ“… 2010 πŸ› Elsevier Science 🌐 French βš– 271 KB

An improved synthesis of 3-(substituted)pyrimido[4,5-c]pyridazine-5,7(1H,6H)-diones, a known subclass of 4-deazatoxoflavins, is reported. The approach involves treatment of 3-methyl-6-(1-methylhydrazinyl)uracil with representative phenyl and alkyl glyoxal monohydrates, which in turn are obtained by