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Parallel Self-Induction of TNF-α and Apoptosis in the Thymus of Mice after Burn Injury

✍ Scribed by Kiho Cho; Lee K. Adamson; David G. Greenhalgh

Book ID
115636398
Publisher
Elsevier Science
Year
2001
Tongue
English
Weight
203 KB
Volume
98
Category
Article
ISSN
0022-4804

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✍ Raja Fayad; Joseph A. Sennello; Soo-Hyun Kim; Maria Pini; Charles A. Dinarello; 📂 Article 📅 2005 🏛 John Wiley and Sons 🌐 English ⚖ 484 KB

Administration of concanavalin A (Con A) is a well-established model of acute immune-mediated hepatitis. Here, we demonstrate that intravenous injection of Con A in mice induces profound thymic atrophy. Compared to liver damage, the kinetics of Con A-induced thymic atrophy is slower and more prolong