Paradoxical sleep deprivation induces muscle atrophy

✍ Scribed by Murilo Dattilo; Hanna Karen Moreira Antunes; Alessandra Medeiros; Marcos Mônico-neto; Helton de SÁ Souza; Kil Sun Lee; Sergio Tufik; Marco Túlio de Mello

• Publisher: John Wiley and Sons
• Year: 2012
• Tongue: English
• Weight: 833 KB
• Volume: 45
• Category: Article
• ISSN: 0148-639X
• DOI: 10.1002/mus.22322

✦ Synopsis

Abstract

Introduction: Because paradoxical sleep deprivation (PSD) induces a catabolic hormone profile, we sought to evaluate the morphology of the tibialis anterior (TA) muscle and testosterone and corticosterone levels of paradoxical sleep–deprived rats.Methods: Three study groups of rats were established: the first group was sleep deprived for 96 h; the second group was also sleep deprived for 96 h, but then returned to their home‐cage and allowed to sleep for the next 96 h; and the third group was the control group, with a normal sleep cycle. Results: PSD reduced the weight and fiber cross‐sectional area of the TA muscle. Moreover, PSD enhanced plasma corticosterone and reduced serum testosterone levels. The 96 h of sleep after PSD was sufficient to restore partially the morphology of TA, while hormones returned to basal levels. Conclusion: PSD induces hormonal alterations that may mediate muscle atrophy. Muscle Nerve, 2012