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Paradoxical response of malignant melanoma to methotrexate in vivo and in vitro

✍ Scribed by Gaukroger, J; Wilson, L; Stewart, M; Farid, Y; Habeshaw, T; Harding, N; Mackie, R

Book ID
109835402
Publisher
Nature Publishing Group
Year
1983
Tongue
English
Weight
983 KB
Volume
47
Category
Article
ISSN
0007-0920

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## Abstract Rodent cell lines can develop resistance to doxorubicin and methotrexate during hypoxic stress. This has so far not been observed in human tumor cell lines. The purpose of our communication is to show that doxorubicin and methotrexate resistance can also develop in human melanoma cells