Paradoxical opiate specific paralytic effects of high doses of intracerebroventricular etorphine and fentanyl in rats

Paradoxical and subtype-specific effects

Paradoxical and subtype-specific effects of opiate antagonists on the expression of opioid receptors in rat brain cultures

✍ J. Barg; R. Levy; Dr. R. Simantov 📂 Article 📅 1989 🏛 John Wiley and Sons 🌐 English ⚖ 828 KB

Cultures of aggregating fetal rat brain cells express p, 6, and K opioid receptors. The potent and longlasting opioid antagonist naltrexone was used to investigate whether different regulatory mechanisms are involved in the expression of the three receptor subtypes. In cultures treated for seven day