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Paradoxical effect of ethanol on potassium channel currents and cell survival in cerebellar granule neurons

✍ Scribed by Thomas Lefebvre; Bruno J. Gonzalez; David Vaudry; Laurence Desrues; Antony Falluel-Morel; Nicolas Aubert; Alain Fournier; Marie-Christine Tonon; Hubert Vaudry; Hélène Castel


Book ID
111183525
Publisher
John Wiley and Sons
Year
2009
Tongue
English
Weight
886 KB
Volume
110
Category
Article
ISSN
0022-3042

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The effect of potassium depolarization and N-methyl-D-aspartate (NMDA) on the activity of aspartate aminotransferase (AAT; EC 2.6.1.1), an enzyme suggested to be involved in neurotransmitter glutamate synthesis, was studied in cultured cerebellar granule neurons. Both KCI and NMDA increased AAT acti