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Paradoxical analgesic effects of micro-doses of naloxone in a model of acute and localized hyperalgesic inflammation: behavioural and electrophysiological studies

✍ Scribed by Guilbaud, G.; Kayser, V.; Benoist, J.M.; Gautron, M.; Neil, A.

Book ID
121897115
Publisher
Elsevier Science
Year
1987
Tongue
English
Weight
88 KB
Volume
30
Category
Article
ISSN
0304-3959

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Behavioural and electrophysiological stu
Behavioural and electrophysiological studies on the paradoxical antinociceptive effects of an extremely low dose of naloxone in an animal model of acute and localized inflammation
✍ V. Kayser; J. M. Benoist; A. Neil; M. Gautron; G. Guilbaud πŸ“‚ Article πŸ“… 1988 πŸ› Springer-Verlag 🌐 English βš– 737 KB

We have previously described the paradoxical antinociceptive effect of low doses of an opiate antagonist, naloxone, in rats suffering from chronic arthritis induced by Freund's adjuvant. In the present work, the appearance of this naloxone sensitivity was studied, using a model of inflammatory hyper