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Paradoxical absence of aggression during naloxone-precipitated morphine withdrawal

✍ Scribed by Gerald Gianutsos; Martin D. Hynes; Richard B. Drawbaugh; Harbans Lal


Publisher
Springer
Year
1975
Tongue
English
Weight
333 KB
Volume
43
Category
Article
ISSN
0033-3158

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✦ Synopsis


Aggression, which is normally seen during withdrawal from narcotics, could not be produced in morphine-dependent rats by the administration of naloxone at doses which causes other signs of withdrawal. Apomorphine injected instead of naloxone was capable of producing aggression, without other withdrawal signs. Naturally occurring aggression (72-hr withdrawal) was enhanced by apomorphine and unaffected by naloxone.


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