Discovery of the inhibitors of tumor nec
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Hwanho Choi; Youngseop Lee; Hwangseo Park; Dal-Seok Oh
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Article
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2010
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Elsevier Science
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English
β 551 KB
Tumor necrosis factor alpha (TNF-a) has been considered as one of the attractive drug targets for allergic diseases including asthma. We have been able to identify five novel TNF-a inhibitors with a drug-design protocol involving the structure-based virtual screening and in vitro cell-based assay fo