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Paracrine influence of human breast stromal fibroblasts on breast epithelial cells: Secretion of a polypeptide which stimulates reductive 17β-oestradiol dehydrogenase activity

✍ Scribed by Eric F. Adams; C. J. Newton; G. H. Tait; H. Braunsberg; M. J. Reed; V. H. T. James

Publisher: John Wiley and Sons
Year: 1988
Tongue: French
Weight: 488 KB
Volume: 42
Category: Article
ISSN: 0020-7136
DOI: 10.1002/ijc.2910420122

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✦ Synopsis

MATERIAL AND METHODS

Culture of human breast fibroblasts and MCF-7 cells

Fibroblasts were grown from surgically removed, malignant breast tumours, as previously described XAdams et al., 1388). Briefly, resected breast tumour tissue was immediately placed

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## Abstract Previous studies have demonstrated that cultured human breast fibroblasts secrete a high‐molecular‐weight polypeptide which stimulates the ability of human breast‐cancer MCF‐7 cells to convert oestrone (E1) to the biologically more active 17β‐oestradiol (E2). This effect is mediated by