✦ LIBER ✦

Paracetamol hepatotoxicity: A built-in antidote?

✍ Scribed by Roger Williams

Publisher: John Wiley and Sons
Year: 1986
Tongue: English
Weight: 414 KB
Volume: 6
Category: Article
ISSN: 0270-9139
DOI: 10.1002/hep.1840060438

No coin nor oath required. For personal study only.

✦ Synopsis

The absence of HBcAg/putative reverse transcriptase fusion proteins in tissues other than hepatomas could be used to support the hypothesis that fusion proteins may not be physiological but an artifact of the extensive gene rearrangements that occur in hepatoma tissues. Despite the evidence that HBV replicates through an RNA intermediate and probably uses a reverse transcriptase as part of its life cycle (5, 6) reverse transcriptase activity in HBV-infected tissues or in Dane particles has not yet been detected. Whether the C-and P-encoded fusion proteins actually have the enzymatic activity and functional significance ascribed to them by Will and colleagues remains to be determined.

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