Paracetamol disposition and metabolite kinetics in patients with chronic renal failure
β Scribed by L. F. Prescott; G. C. Speirs; J. A. J. H. Critchley; R. M. Temple; R. J. Winney
- Publisher
- Springer
- Year
- 1989
- Tongue
- English
- Weight
- 943 KB
- Volume
- 36
- Category
- Article
- ISSN
- 0031-6970
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
We have compared the disposition of oral paracetamol (1.0 g t.d.s. for 10 days) in 6 healthy volunteers and 6 conservatively-managed patients with chronic renal failure (mean plasma creatinine 451 mumol.l-1). Blood was sampled daily for 10 days before the morning dose of paracetamol. Each day the pr
The pharmacokinetics of an intravenous injection of disopyramide was studied in five normal subjects and six patients with varying degrees of renal impairment. The elimination rate constant (p) was related to the endogenous creatinine clearance (Cl,,). However, a decrease in / 3 was not observed un
The pharmacokinetics of oral diltiazem were studied in 10 patients with chronic renal failure not requiring dialysis and in five healthy volunteers after a single dose of 120mg. We found that patients with chronic renal failure had lower amounts of unchanged diltiazem and of its main metabolite (MA)