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Papillon-Lefèvre syndrome with albinism: A review of the literature and report of 2 brothers

✍ Scribed by Faiez N. Hattab; Wala M. Amin


Book ID
116940834
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
573 KB
Volume
100
Category
Article
ISSN
1528-395X

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Papillon Lefèvre syndrome (PLS) is an autosomal recessive disorder characterized by palmoplantar hyperkeratosis and severe periodontitis. The disease is caused by mutations in the cathepsin C gene (CTSC) that maps to chromosome 11q14. CTSC gene mutations associated with PLS have been correlated with