Papillary carcinoma of the thyroid gland. Sizes of 525 tumors found at autopsy in Hiroshima and Nagasaki
✍ Scribed by Dr. Richard J. Sampson; Dr. Charles R. Key; Dr. C. Ralph Buncher; Dr. Hisao Oka; Soichi Iijima
- Publisher
- John Wiley and Sons
- Year
- 1970
- Tongue
- English
- Weight
- 266 KB
- Volume
- 25
- Category
- Article
- ISSN
- 0008-543X
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✦ Synopsis
Five hundred twenty-five cases of papillary carcinoma of the thyroid, diagnosed at autopsy in Hiroshima and Nagasaki, Japan, were investigated f o r sex differences; 274 cases were found in 1,453 females, 251 in 1,614 males. The greatest dimensions of the tumors by sex have lognormal distributions, with m e a n 0.20 cm for females and 0.13 cm for males. Tumors in females were, as a population, significantly larger than tumors in males (p < .001). The data are in agreement with the presence of a growth-promoting factor which is greater in females than in males. Tumors initiated by radiation and those initiated by other causes seem to be equally promoted by this factor.
HE MARKED PREPONDERANCE OF CLINI-
T cally evident papillary carcinomas of the thyroid in females suggests that these neoplasms, thought to he endocrine dependent,3* 12 are affected differently by the internal environments of males and females. Sloan's finding11 that the sex difference in incidence of the tumor is far less in children and in the aged than in the reproductive years supports this concept. In experimental studies of thyroid carcinogenesis,*~ 6 growth promotion is regarded as dependent on a hormonal factor independent of the carcinogen which initiated the tumor. There is