Pancytopenia due to bone marrow necrosis in acute myelogenous leukemia: Role of reactive CD8 cells
✍ Scribed by Markovic, S. N.; Phyliky, R. L.; Li, C. Y.
- Publisher
- John Wiley and Sons
- Year
- 1998
- Tongue
- English
- Weight
- 517 KB
- Volume
- 59
- Category
- Article
- ISSN
- 0361-8609
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✦ Synopsis
Bone marrow necrosis is a rare clinical condition often associated with hematological malignancy. The mechanism by which malignant disease causes marrow necrosis is unknown. We present a case of a patient with newly diagnosed pancytopenia with bone marrow biopsy evidence of extensive marrow necrosis. Upon further work-up utilizing Tc bone scan directed bone marrow biopsy, a massive CD8+ T cell marrow infiltrate was discovered engulfing AML-M2 blasts. The role of Tc bone scans in the work-up of bone marrow necrosis as well as the potential mechanism of AML-M2 induced marrow necrosis in the setting of reactive CD8+ T cell infiltration is discussed.